Anti-Leishmanial activity of homo- and heteroleptic bismuth(III) carboxylates
Philip C Andrews, Rene Frank, Peter C Junk, Lukasz Kedzierski, Ish Kumar, Jonathan G MacLellan
JOURNAL OF INORGANIC BIOCHEMISTRY | ELSEVIER SCIENCE INC | Published : 2011
Bismuth(III) complexes of NSAIDs (Non-Steroidal Anti Inflammatory Drugs) and substituted benzoic acids (o-methoxybenzoic acid, m-methoxybenzoic acid, o-nitrobenzoic acid, 3,5-diacetamidobenzoic acid, and 5-[(R/S)-2,3-dihydroxypropyl carbamoyl]-2-pyridine carboxylic acid) have been synthesised and fully characterised. Two new bis-carboxylato bismuth complexes have been characterised by single crystal X-ray diffraction, namely [PhBi(o-MeOC(6)H(4)CO(2))(2)(bipy)]·0.5EtOH (bipy=2,2'-bipyridine) and [PhBi(C(9)H(11)N(2)O(3)CO(2))(2)(H(2)O)]·6H(2)O. All compounds were tested against the parasite Leishmania major promastigotes for their anti-Leishmanial activity and were further assessed for their t..View full abstract
We thank the Australian Research Council and Monash University for financial support. We would also like to thank to Prof. Glen Deacon (Monash) for many helpful discussions, and Dr Chris Tonkin (WEHI) for the supply of human primary fibroblast cells.