Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
Caitlin L Maikawa, Scott Weichenthal, Amanda J Wheeler, Nina A Dobbin, Audrey Smargiassi, Greg Evans, Ling Liu, Mark S Goldberg, Krystal J Godri Pollitt
ENVIRONMENTAL HEALTH PERSPECTIVES | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | Published : 2016
BACKGROUND: Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5; aerodynamic diameter ≤ 2.5 μm) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to describe the capacity of PM2.5 to generate reactive oxygen species in the lung. OBJECTIVE: In this study we investigated the association between airway inflammation in asthmatic children and oxidative burden of PM2.5 personal exposure. METHODS: Daily PM2.5 personal exposure samples (n = 249) of 62 asthmatic school-aged children in Montreal were collected over 10 consecutive days. The oxidative bu..View full abstract
The Canadian Clean Air Regulatory Agenda funded this study.