Influence of personal exposure to particulate air pollution on cardiovascular physiology and biomarkers of inflammation and oxidative stress in subjects with diabetes.
Ling Liu, Terrence D Ruddy, Mary Dalipaj, Mieczyslaw Szyszkowicz, Hongyu You, Raymond Poon, Amanda Wheeler, Robert Dales
J Occup Environ Med | Published : 2007
OBJECTIVE: We investigated whether personal exposure to particulate matter = 10 microm in diameter (PM10) contributes to impaired cardiovascular function and increased systemic inflammation and oxidative stress in diabetic patients. METHODS: We monitored 25 patients' personal exposure to PM10 for 24 hours and then measured their heart rate, blood pressure, brachial arterial diameter, flow-mediated vasodilation (FMD), plasma cytokines, and thiobarbituric acid reactive substances (TBARS), which is an oxidative stress marker. We repeated this procedure for 7 weeks on each subject. We tested the associations using mixed-effects models. RESULTS: PM10 was significantly positively associated with..View full abstract