The Inflammatory Bowel Diseases and Ambient Air Pollution: A Novel Association
Gilaad G Kaplan, James Hubbard, Joshua Korzenik, Bruce E Sands, Remo Panaccione, Subrata Ghosh, Amanda J Wheeler, Paul J Villeneuve
AMERICAN JOURNAL OF GASTROENTEROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
OBJECTIVES: The inflammatory bowel diseases (IBDs) emerged after industrialization. We studied whether ambient air pollution levels were associated with the incidence of IBD. METHODS: The health improvement network (THIN) database in the United Kingdom was used to identify incident cases of Crohn's disease (n=367) or ulcerative colitis (n=591), and age- and sex-matched controls. Conditional logistic regression analyses assessed whether IBD patients were more likely to live in areas of higher ambient concentrations of nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), and particulate matter <10 μm (PM(10)), as determined by using quintiles of concentrations, after adjusting for smoking, socioe..View full abstract
This work was supported by an operating grant from the Broad Medical Research Program of the Broad Foundation and from the CCFC Chair in IBD Research. G.G.K. is supported through a New Investigator Award from the Canadian Institute of Health Research and a Population Health Investigator Award from the Alberta Heritage Foundation for Medical Research.