Sodium reduction during cardiopulmonary bypass: Plasma-lyte 148 versus trial fluid as pump primes

Abstract

Objectives: We compared effects on plasma sodium concentrations plus calculated plasma tonicity of two “balanced” crystalloid solutions used as 2 L pump primes during cardiopulmonary bypass (CPB): Plasma-Lyte 148 (sodium concentration, 140mmol/L; potassium concentration, 5mmol/L) versus a bicarbonate-balanced fluid (sodium concentration, 140mmol/L; potassium concentration, 0mmol/L). Design, setting and participants: We analysed pooled data from two prospective interventional studies performed in university-affiliated hospitals, from 50 patients undergoing elective cardiac surgery. Interventions: Participants were allocated equally to Plasma-Lyte 148 or bicarbonate-balanced fluid, with plasma..