Journal article

Disagreement between ion selective electrode direct and indirect sodium measurements: Estimation of the problem in a tertiary referral hospital

Goce Dimeski, Thomas J Morgan, Jeffrey J Presneill, Balasubramanian Venkatesh

JOURNAL OF CRITICAL CARE | W B SAUNDERS CO-ELSEVIER INC | Published : 2012

Abstract

PURPOSE: We estimated the proportion of indirect ion selective electrode (ISE) plasma sodium analyses in intensive care unit (ICU) and hospital wide, exhibiting important disagreement with direct ISE results in relation to abnormal plasma protein concentrations. MATERIALS AND METHODS: Direct and indirect ISE plasma sodium measurements were performed on 346 clinical specimens selected to reflect low, normal, or high total protein concentrations. Important intermethod disagreement was defined as |4| mmol/L or higher. Results were extrapolated to a 3-month laboratory series of 48,033 indirect ISE assays, including 2877 samples from intensive care. RESULTS: Intermethod sodium disagreement at |4|..

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University of Melbourne Researchers