Journal article

A NEW FORMULATION OF ASPIRIN - BIOAVAILABILITY AND ANALGESIC EFFICACY IN MIGRAINE ATTACKS

RA BRANDON, MJ EADIE, ACW CURRAN, PC NOLAN, JJ PRESNEILL, MC PATTERSON

CEPHALALGIA | SCANDINAVIAN UNIVERSITY PRESS | Published : 1986

Abstract

Plasma aspirin and salicylate concentrations were followed after 600 mg of a new palatable glycinated preparation of aspirin was given to six healthy male volunteers in an attempt to investigate whether pre-gastric absorption of aspirin could occur. In each subject the drug was administered by three different routes, viz. (i) swallowed with water, (ii) dissolved sublingually and retained in the mouth, and (iii) allowed to disperse on the tongue, and then swallowed without water intake. Using the latter route of administration and the same aspirin formulation, plasma aspirin and salicylate concentrations were also followed in 10 patients during acute migraine attacks. These results were compa..

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