Polyvinyl Alcohol as a Biocompatible Alternative for the Passivation of Gold Nanorods
Calum Kinnear, David Burnand, Martin JD Clift, Andreas FM Kilbinger, Barbara Rothen-Rutishauser, Alke Petri-Fink
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | WILEY-V C H VERLAG GMBH | Published : 2014
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor, polyvinyl acetate, which is then transformed into its hydrophilic analogue, polyvinyl alcohol. This polymer was chosen due to its well-established biocompatibility, tunable "stealth" properties, tunable hydrophobicity, and high degree of functionality. The biocompatibility of the functionalized GNRs was tes..View full abstract
Awarded by Swiss National Science Foundation
This work was supported by the Swiss National Science Foundation (PP00P2_123373), the Adolphe Merkle Institute, and FriMat.