Journal article

Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression

Jeremy Ng Chi Kei, Peter David Currie, Patricia Regina Jusuf

NEURAL DEVELOPMENT | BIOMED CENTRAL LTD | Published : 2017

Abstract

BACKGROUND: Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural retina of zebrafish, Müller glia are the main stem cell source and are capable of generating progenitors to replace lost neurons after injury. However, it remains largely unknown to what extent Müller glia and neuron differentiation mirror development. METHODS: Following neural ablation in the zebrafish retina, dividing cells were tracked using a prolonged labelling technique. We investigated to what extent extrinsic feedback influences fate choices in two injury models, and..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council Discovery Early Career Research Fellowship


Funding Acknowledgements

This work was supported by a Faculty of Medicine International Postgraduate Research Scholarship, Monash University to JNCK, and Australian Research Council Discovery Early Career Research Fellowship (DE120101311 to PRJ). The Australian Regenerative Medicine Institute is supported by grants from the State Government of Victoria and the Australian Federal Government.