Nano-scale clustering of integrin-binding ligands regulates endothelial cell adhesion, migration, and endothelialization rate: novel materials for small diameter vascular graft applications
Fatemeh Karimi, Thomas G McKenzie, Andrea J O'Connor, Greg G Qiao, Daniel E Heath
JOURNAL OF MATERIALS CHEMISTRY B | ROYAL SOC CHEMISTRY | Published : 2017
Blood contacting devices are commonly used in today's medical landscape. However, such devices (including small diameter vascular grafts) are limited by poor blood compatibility and may fail due to thrombosis. An attractive strategy for improving the blood compatibility of such devices is to generate biomaterials that foster a confluent and functioning endothelial cell layer. Synthesizing materials that display integrin-binding peptide ligands is a common way to promote endothelialization. However, in addition to integrin-ligand binding, integrin clustering is necessary to achieve intracellular signaling events that influence cellular phenotype. In this study, we explored the impact of nano-..View full abstract
We would like to thank the University of Melbourne Early Career Researchers Award, Equity Trustees, and the Therapeutic Technologies Hallmark Research Initiative for financial support.