Journal article

Nano-scale clustering of integrin-binding ligands regulates endothelial cell adhesion, migration, and endothelialization rate: novel materials for small diameter vascular graft applications

Fatemeh Karimi, Thomas G McKenzie, Andrea J O'Connor, Greg G Qiao, Daniel E Heath

JOURNAL OF MATERIALS CHEMISTRY B | ROYAL SOC CHEMISTRY | Published : 2017

Abstract

Blood contacting devices are commonly used in today's medical landscape. However, such devices (including small diameter vascular grafts) are limited by poor blood compatibility and may fail due to thrombosis. An attractive strategy for improving the blood compatibility of such devices is to generate biomaterials that foster a confluent and functioning endothelial cell layer. Synthesizing materials that display integrin-binding peptide ligands is a common way to promote endothelialization. However, in addition to integrin-ligand binding, integrin clustering is necessary to achieve intracellular signaling events that influence cellular phenotype. In this study, we explored the impact of nano-..

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Grants

Funding Acknowledgements

We would like to thank the University of Melbourne Early Career Researchers Award, Equity Trustees, and the Therapeutic Technologies Hallmark Research Initiative for financial support.