Journal article

Plectin transcript diversity: Identification and tissue distribution of variants with distinct first coding exons and rodless isoforms

CE Elliott, B Becker, S Oehler, MJ Castanon, R Hauptmann, G Wiche

GENOMICS | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1997

Abstract

Plectin is a widely expressed protein that is very large in size and that has all the attributes of a multifunctional crosslinking and organizing element of the cytoskeleton. It displays a multidomain structure, versatile binding activities, and subcellular localizations that enable it to strengthen cells against mechanical stress forces. Moreover, hereditary gene defects in plectin cause epidermolysis bullosa simplex (EBS)-MD, a severe skin blistering disease with muscular dystrophy. Here we report the analysis of the exonintron organization of the rat plectin gene and the identification of several different isoforms on the transcriptional level. We show that of 35 coding exons identified, ..

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University of Melbourne Researchers