Journal article

Selective pressures at a codon-level predict deleterious mutations in human disease genes

Leonardo Arbiza, Serena Duchi, David Montaner, Jordi Burguet, David Pantoja-Uceda, Antonio Pineda-Lucena, Joaquin Dopazo, Hernan Dopazo

Journal of Molecular Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2006

DOI: 10.1016/j.jmb.2006.02.067

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Keywords

Sequence Variation
Biochemistry & Molecular Biology
Comparative Genomics
Deleterious Mutations
Life Sciences & Biomedicine
Databases, Genetic
Codon
Models, Molecular
Evolution, Molecular
Humans
Models, Genetic
Proteins
Human Diseases
Tumor Suppressor Protein P53
Mutation
Positive Selection
Genome, Human
Science & Technology
Codon-Based Models
Molecular Sequence Data
Nonsynonymous Substitution
Neoplasms
Likelihood
Evolution
Amino Acid Sequence
Single-Nucleotide Polymorphisms
Genes, P53
Selection, Genetic
Rates
Amino Acid Substitution
Genetic Diseases, Inborn
Dna
Purifying Selection
Amino-Acid Sites
P53