Journal article

Selective pressures at a codon-level predict deleterious mutations in human disease genes

Leonardo Arbiza, Serena Duchi, David Montaner, Jordi Burguet, David Pantoja-Uceda, Antonio Pineda-Lucena, Joaquin Dopazo, Hernan Dopazo

Journal of Molecular Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2006

DOI: 10.1016/j.jmb.2006.02.067

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Keywords

Mutation
Genes, P53
Models, Molecular
Codon-Based Models
Amino-Acid Sites
Single-Nucleotide Polymorphisms
Amino Acid Sequence
Comparative Genomics
Models, Genetic
Codon
Evolution
Likelihood
Purifying Selection
Humans
Selection, Genetic
Genetic Diseases, Inborn
P53
Amino Acid Substitution
Nonsynonymous Substitution
Databases, Genetic
Tumor Suppressor Protein P53
Deleterious Mutations
Sequence Variation
Molecular Sequence Data
Proteins
Biochemistry & Molecular Biology
Positive Selection
Rates
Evolution, Molecular
Science & Technology
Dna
Neoplasms
Human Diseases
Life Sciences & Biomedicine
Genome, Human