Journal article
Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study
Tatiane Yanes, Bettina Meiser, Mary-Anne Young, Rajneesh Kaur, Gillian Mitchell, Kristine Barlow-Stewart, Tony Roscioli, Jane Halliday, Paul James
BMC CANCER | BMC | Published : 2017
Abstract
BACKGROUND: The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testing for common risk variants can provide useful information for women who would otherwise receive uninformative results by traditional monogenic testing. Despite increasing support for the utility of common risk variants in hereditary breast cancer, research findings have not yet been integrated into clinical practice. Translational research is therefore critical to ensure resu..
View full abstractGrants
Awarded by Cancer Council of New South Wales
Awarded by National Medical and Research Council
Awarded by National Breast Cancer Foundation
Funding Acknowledgements
This study is supported by a grant from the Cancer Council of New South Wales (grant number APP1079897). The Variants in Practice study is supported by a National Medical and Research Council grant (APP1023698, 2012-2014). TY is supported by a National Health and Medical Research Council and National Breast Cancer Foundation postgraduate scholarship. The granting bodies are not involved in the design of the study, and collection, analysis or interpretation of data.