Journal article

Deciphering the clinical relevance of allo-human leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation

Louise C Rowntree, Thi HO Nguyen, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud

CURRENT OPINION IN ORGAN TRANSPLANTATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Abstract

PURPOSE OF REVIEW: Despite a growing awareness regarding the potential of cross-reactive virus-specific memory T cells to mediate alloimmunity, there has been limited clinical evaluation on allograft immunopathology. This review will explore published models of human T-cell cross-reactivity and discuss criteria required to drive this mechanism as a contributing cause of allograft dysfunction in transplantation. RECENT FINDINGS: Published models of human allogeneic (allo)-human leukocyte antigen (HLA) cross-reactivity have enabled dissection of the cross-reactive T cell receptor/peptide/major histocompatibility complex (TCR/peptide/MHC) interaction. In many of the models, the cross-reactive T..

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