Journal article

Impact of Commonly Used Transplant Immunosuppressive Drugs on Human NK Cell Function Is Dependent upon Stimulation Condition

Aislin C Meehan, Nicole A Mifsud, Thi HO Nguyen, Bronwyn J Levvey, Greg I Snell, Tom C Kotsimbos, Glen P Westall

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

Lung transplantation is a recognised treatment for patients with end stage pulmonary disease. Transplant recipients receive life-long administration of immunosuppressive drugs that target T cell mediated graft rejection. However little is known of the impact on NK cells, which have the potential to be alloreactive in response to HLA-mismatched ligands on the lung allograft and in doing so, may impact negatively on allograft survival. NK cells from 20 healthy controls were assessed in response to Cyclosporine A, Mycophenolic acid (MPA; active form of Mycophenolate mofetil) and Prednisolone at a range of concentrations. The impact of these clinically used immunosuppressive drugs on cytotoxicit..

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Funding Acknowledgements

This work has been supported by the National Health and Medical Research Council (NHMRC) with the provision of the Dora Lush Postgraduate Research Scholarship and the Margaret Pratt Foundation (http://www.mprattfoundation.com.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.