Journal article

XIAP Loss Triggers RIPK3-and Caspase-8-Driven IL-1 beta Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

Kate E Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A Conos, Kaiwen W Chen, Stephanie Ziehe, Carina Grass, Yifan Zhan, Tan A Nguyen, Cathrine Hall, Angelina J Vince, Simon M Chatfield, Damian B D'Silva, Kenneth C Pang, Kate Schroder, John Silke, David L Vaux, Philipp J Jost, James E Vince

Cell Reports | CELL PRESS | Published : 2017

Grants

Awarded by National Health and Medical Research


Awarded by operational infrastructure grants through the Australian Government IRISS


Awarded by Max Eder-Program grant from the Deutsche Krebshilfe


Awarded by Deutsche Jose Carreras Leukamie Stiftung (DJCLS)


Awarded by DFG


Awarded by Else Kroner-Fresenius-Stiftung



Funding Acknowledgements

We thank F. Moghaddas, L. Lindqvist, and B. Croker for comments on the manuscript and A. Mildenhall for technical assistance; R. Crawley, L. Wilkins, C. Yates, S. Oliver, C. Stivila, and N. Lynch for animal care; J. Corbin for Advia cell counts; TetraLogic Pharmaceuticals and Novartis for Smac mimetic compounds; S. Monard and staff for cell sorting; L. Wong for RT- PCR primer sequences and discussions; B. Kile for Ifnar1 -/- mice; and D. De Nardo for advice and reagents; This work was supported by National Health and Medical Research Project grants (1051210, 1101405, 1064591, and 1081272), fellowships to J.E.V. (1052598), a Program Grant to D.L.V. (461221), and operational infrastructure grants through the Australian Government IRISS (9000220) and the Victorian State Government OIS. P.J.J. was supported by a Max Eder-Program grant from the Deutsche Krebshilfe (program 111738), and P.J.J. and M.Y. were supported by grants from the Deutsche Jose Carreras Leukamie Stiftung (DJCLS R 12/22), the DFG (FOR2036), and the Else Kroner-Fresenius-Stiftung (2014_A185).