Journal article

Implementing a successful data-management framework: the UK10K managed access model

Dawn Muddyman, Carol Smee, Heather Griffin, Jane Kaye

Genome Medicine: medicine in the post-genomic era | BIOMED CENTRAL LTD | Published : 2013


This paper outlines the history behind open access principles and describes the development of a managed access data-sharing process for the UK10K Project, currently Britain's largest genomic sequencing consortium (2010 to 2013). Funded by the Wellcome Trust, the purpose of UK10K was two-fold: to investigate how low-frequency and rare genetic variants contribute to human disease, and to provide an enduring data resource for future research into human genetics. In this paper, we discuss the challenge of reconciling data-sharing principles with the practicalities of delivering a sequencing project of UK10K's scope and magnitude. We describe the development of a sustainable, easy-to-use managed..

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University of Melbourne Researchers


Awarded by Wellcome Trust

Funding Acknowledgements

Funding for the UK10K Project was provided by the Wellcome Trust under award WT091310. JK is funded under Wellcome Trust Award 096599/2/11/Z. A full list of consortium members can be found at the UK10K Project website [2].