Interaction of reelin and stress on immobility in the forced swim test but not dopamine-mediated locomotor hyperactivity or prepulse inhibition disruption: Relevance to psychotic and mood disorders
Michael J Notaras, Billie Vivian, Carey Wilson, Maarten van den Buuse
Schizophrenia Research | ELSEVIER | Published : 2020
RATIONALE: Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders. METHODS: Heterozygous Reeler Mice (HRM) and wildtype (WT) controls were treated with 50mg/L of corticosterone (CORT) in their drinking wat..View full abstract
Author Notaras was supported by an Australian Postgraduate Award. Author van den Buuse was supported by a Senior Research Fellowship fromthe National Health and Medical Research Council of Australia. Project funding was provided by the School of Psychology and Public Health at La Trobe University, Melbourne, Australia. None of these funding bodies had any influence on the design of the study, its execution, data analysis, or the writing of the manuscript.