Journal article
Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers
K Landucci Bonifácio, D Sabbatini Barbosa, E Gastaldello Moreira, CC de Farias, L Higachi, AEI Camargo, J Favaro Soares, H Odebrecht Vargas, SOV Nunes, M Berk, S Dodd, M Maes
Journal of Affective Disorders | ELSEVIER | Published : 2017
Abstract
Background Insulin resistance (IR) is a key factor in diabetes mellitus, metabolic syndrome (MetS) and obesity and may occur in mood disorders and tobacco use disorder (TUD), where disturbances of immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways are important shared pathophysiological pathways. Methods This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or witho..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
KLB is supported by CNPq, Scholarship 203826/2015-9. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. DSB and SOVN are senior fellows from Fundacao Araucaria. MM is supported by a Special Visiting Researcher (PVE) fellowship from Conselho Nacional de Pesquisa e Desenvolvimento at the Graduation Program in Health Sciences, UEL. This study was funded by grants from 404877/2013-3. The funding sources had no involvement in study design; and collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.