Journal article

Structural and Ultrastructural Changes to Type I Spiral Ganglion Neurons and Schwann Cells in the Deafened Guinea Pig Cochlea

Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY | SPRINGER | Published : 2017

Abstract

Sensorineural hearing loss is commonly caused by damage to cochlear sensory hair cells. Coinciding with hair cell degeneration, the peripheral fibres of type I spiral ganglion neurons (SGNs) that normally form synaptic connections with the inner hair cell gradually degenerate. We examined the time course of these degenerative changes in type I SGNs and their satellite Schwann cells at the ultrastructural level in guinea pigs at 2, 6, and 12 weeks following aminoglycoside-induced hearing loss. Degeneration of the peripheral fibres occurred prior to the degeneration of the type I SGN soma and was characterised by shrinkage of the fibre followed by retraction of the axoplasm, often leaving a no..

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Grants

Awarded by NIDCD


Awarded by NHMRC


Awarded by NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS


Funding Acknowledgements

We are grateful for contributions made by Cong Ho, Anna Friedhuber, Marie Camilleri, Nicole Critch, Alison Neil, Stephen Asquith, Sarah Ellis, Maria Clarke, Prue Nielsen, and Ella Trang. The authors would like to acknowledge the funding support from the NIDCD (HHS-N-263-2007-00053-c and R01DC015031) and the NHMRC (GNT1064375). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.