Journal article
Human haematopoietic stem cell development: From the embryo to the dish
A Ivanovs, S Rybtsov, ES Ng, EG Stanley, AG Elefanty, A Medvinsky
Development Cambridge | COMPANY BIOLOGISTS LTD | Published : 2017
DOI: 10.1242/dev.134866
Abstract
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental importance for basic biology and medical sciences, but our knowledge is still limited compared with what we know of adult HSCs and their microenvironment. This is particularly true for human haematopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from pluripotent stem cells in vitro. In this Review, we discuss what is known of human haematopoietic development: the anatomical sites at which it occurs, the different temporal waves of haematopoiesis, the emergence of th..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by Bloodwise (formerly LLR) and Medical Research Council (UK). E.G.S. and A.G.E. are Research Fellows of the National Health and Medical Research Council (Australia). Work in the laboratories of E.G.S. and A.G.E. is supported by the National Health and Medical Research Council (Australia), Stem Cells Australia and the Children's Cancer Foundation.