Journal article
Association of antibiotics, airway microbiome, and inflammation in infants with cystic fibrosis
JE Pittman, KM Wylie, K Akers, GA Storch, J Hatch, J Quante, KB Frayman, N Clarke, M Davis, SM Stick, GL Hall, G Montgomery, S Ranganathan, SD Davis, TW Ferkol
Annals of the American Thoracic Society | AMER THORACIC SOC | Published : 2017
Abstract
Rationale: The underlying defect in the cystic fibrosis (CF) airway leads to defective mucociliary clearance and impaired bacterial killing, resulting in endobronchial infection and inflammation that contributes to progressive lung disease. Little is known about the respiratory microbiota in the early CF airway and its relationship to inflammation. Objectives: To examine the bacterial microbiota and inflammatory profiles in bronchoalveolar lavage fluid and oropharyngeal secretions in infants with CF. Methods: Infants with CF from U.S. and Australian centers were enrolled in a prospective, observational study examining the bacterial microbiota and inflammatory profiles of the respiratory trac..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors were supported by National Institutes of Health grants HL116211 (T.W.F., S.D.D., and S.R.) and HL120002 (J.E.P.); National Health and Medical Research Council awards NHMRC1043768 (S.R.), NHMRC1000896 (S.M.S.), and NHMRC APP1025550 (G.L.H.); the Children's Discovery Institute (J.E.P.); the Indiana Physician Scientist Award (Eli Lilly) (S.D.D.); the Thoracic Society of Australia and New Zealand Vertex Cystic Fibrosis Pediatric Clinical Fellowship (K.B.F.); the Australian Cystic Fibrosis Research Trust Postgraduate Studentship (K.B.F.); and the Royal Children's Hospital Cystic Fibrosis Research Trust.