Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina
Kerry J Halupka, Carla J Abbott, Yan T Wong, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Evgeni N Sergeev, Chi D Luu, Alice Brandli, Penelope J Allen, Hamish Meffin, Mohit N Shivdasani
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017
Purpose: Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolution of retinal prostheses. However, the effects of simultaneous stimulation on degenerate retinae remain unknown. Therefore, we investigated the characteristics of cortical responses to multielectrode stimulation of the degenerate retina. Methods: Four adult cats were bilaterally implanted with retinal electrode arrays in the suprachoroidal space after unilateral adenosine triphosphate (ATP)-induced retinal photoreceptor degeneration. Functional and structural changes were characterized by using electroretinogram a-wave amplitude and optical coherence tomography...View full abstract
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Awarded by National Health and Medical Research Council, Australia (GNT)
Awarded by Australian Research Council's Discovery Projects funding scheme
Supported by a Project Grant from the National Health and Medical Research Council, Australia (GNT No. 1063093). This research was additionally supported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology awarded to Bionic Vision Australia and the Bertalli Family Foundation to the Bionics Institute. The Bionics Institute and the Centre for Eye Research Australia acknowledge the support they receive from the Victorian Government through its Operational Infrastructure Program. KJH was supported by an Australian Postgraduate Award through the Australian Government and a postgraduate scholarship from the Commonwealth Scientific and Industrial Research Organisation (CSIRO). ANB and YTW acknowledge support under the Australian Research Council's Discovery Projects funding scheme (Project DP140104533).