Journal article
Role of the β common (βc) family of cytokines in health and disease
TR Hercus, WLT Kan, SE Broughton, D Tvorogov, HS Ramshaw, JJ Sandow, TL Nero, U Dhagat, EJ Thompson, KSC Tung Shing, DR McKenzie, NJ Wilson, CM Owczarek, G Vairo, AD Nash, V Tergaonkar, T Hughes, PG Ekert, MS Samuel, CS Bonder Show all
Cold Spring Harbor Perspectives in Biology | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2018
Abstract
The b common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use bc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the bc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and..
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Funding Acknowledgements
This work is supported by grants from the National Health and Medical Research Council of Australia (NHMRC), the Australian Cancer Research Foundation, the Leukemia Foundation of Australia, and CSL Limited, as well as funding from Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.