Journal article
An unbiased linkage approach reveals that the p53 pathway is coupled to nk cell maturation
R Collin, C St-Pierre, L Guilbault, V Mullins-Dansereau, A Policheni, F Guimont-Desrochers, AN Pelletier, DH Gray, E Drobetsky, C Perreault, EE Hillhouse, S Lesage
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2017
Abstract
Natural killer cells constitute potent innate lymphoid cells that play a major role in both tumor immunosurveillance and viral clearance via their effector functions. A four-stage model of NK cell functional maturation has been established according to the expression of CD11b and CD27, separating mature NK (mNK) cells into distinct populations that exhibit specific phenotypic and functional properties. To identify genetic factors involved in the regulation of NK cell functional maturation, we performed a linkage analysis on F2 (B6.Rag12/2 3 NOD.Rag12/2 intercross) mice. We identified six loci on chromosomes 2, 4, 7, 10, 11, and 18 that were linked to one or more mNK cell subsets. Subsequentl..
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Awarded by Cancer Research Society
Funding Acknowledgements
This work was supported by research funds from the Cancer Research Society to S.L. (20379) and from the Natural Sciences and Engineering Research Council of Canada (06531). S.L. holds a senior scholarship from the Fonds de Recherche-Sante Quebec, R.C. holds a studentship from the Fonds de Recherche-Sante Quebec, and L.G. and V.M.-D. both hold a scholarship from Diabete Quebec and from l'Universite de Montreal.