Journal article
Effects of liver-stage clearance by Primaquine on gametocyte carriage of Plasmodium vivax and P. falciparum
R Wampfler, NE Hofmann, S Karl, I Betuela, B Kinboro, L Lorry, M Silkey, LJ Robinson, I Mueller, I Felger
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Background: Primaquine (PQ) is the only currently licensed antimalarial that prevents Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes, thereby reducing post-treatment transmission. Randomized PQ treatment in a treatment-to-reinfection cohort in Papua New Guinean children permitted the study of Pv and Pf gametocyte carriage after radical cure and to investigate the contribution of Pv relapses. Methods: Children received radical cure with Chloroquine, Artemether-Lumefantrine plus either PQ or placebo. Blood samples were subsequently collected in 2-to 4-weekly intervals over 8 months. Gametocytes were detected by quantitative reverse transcription-PCR target..
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Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
This work was supported by the International Centers of Excellence in Malaria Research (Award Number: U19 AI089686-03). IF was supported by the Swiss National Science Foundation (Award Numbers: 310030_134889 and 310030_159580). SK was supported by the National Health and Medical Research Council (NHMRC, Award Number: 1052760). LJR was supported by the NHMRC (Award Number: 1016443). IM was supported by the NHMRC (Award Numbers: 1043345 and 1021544). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.