Journal article

Dynamic Coupling between fMRI Local Connectivity and Interictal EEG in Focal Epilepsy: AWavelet Analysis Approach

Amir Omidvarnia, Mangor Pedersen, David N Vaughan, Jennifer M Walz, David F Abbott, Andrew Zalesky, Graeme D Jackson

HUMAN BRAIN MAPPING | WILEY | Published : 2017


Simultaneous scalp EEG-fMRI recording is a noninvasive neuroimaging technique for combining electrophysiological and hemodynamic aspects of brain function. Despite the time-varying nature of both measurements, their relationship is usually considered as time-invariant. The aim of this study was to detect direct associations between scalp-recorded EEG and regional changes of hemodynamic brain connectivity in focal epilepsy through a time-frequency paradigm. To do so, we developed a voxel-wise framework that analyses wavelet coherence between dynamic regional phase synchrony (DRePS, calculated from fMRI) and band amplitude fluctuation (BAF) of a target EEG electrode with dominant interictal ep..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

Contract grant sponsor: National Health and Medical Research Council (NHMRC) of Australia; Contract grant number: 628952; Contract grant sponsor: State Government of Victoria, Australia (Operational Infrastructure Support Grant to The Florey Institute of Neuroscience and Mental Health); Contract grant sponsor: NHMRC (practitioner's fellowship to G.D.J.); Contract grant number: 1060312; Contract grant sponsor: NHMRC postgraduate scholarship and a Windermere Foundation doctoral scholarship (to D.N.V.); Contract grant sponsor: Australian National Imaging Facility (fellowship funding for D.F.A.)