Type IX secretion: the generation of bacterial cell surface coatings involved in virulence, gliding motility and the degradation of complex biopolymers
Paul D Veith, Michelle D Glew, Dhana G Gorasia, Eric C Reynolds
MOLECULAR MICROBIOLOGY | WILEY | Published : 2017
The Type IX secretion system (T9SS) is present in over 1000 sequenced species/strains of the Fibrobacteres-Chlorobi-Bacteroidetes superphylum. Proteins secreted by the T9SS have an N-terminal signal peptide for translocation across the inner membrane via the SEC translocon and a C-terminal signal for secretion across the outer membrane via the T9SS. Nineteen protein components of the T9SS have been identified including three, SigP, PorX and PorY that are involved in regulation. The inner membrane proteins PorL and PorM and the outer membrane proteins PorK and PorN interact and a complex comprising PorK and PorN forms a large ring structure of 50 nm in diameter. PorU, PorV, PorQ and PorZ form..View full abstract
This work was supported by the Supported by the Australian Government, Department of Industry, Innovation and Science. We thank Dr Christine Seers for identifying the correlation between the multiple PorP and PG1058 homologs present in many species.