Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats
Leigh C Walker, Hanna E Kastman, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2017
BACKGROUND AND PURPOSE: Alcohol use disorders are a leading cause of preventable deaths worldwide, and stress is a major trigger of relapse. The neuropeptide relaxin-3 and its cognate receptor, relaxin family peptide receptor 3 (RXFP3), modulate stress-induced relapse to alcohol seeking in rats, and while the bed nucleus of the stria terminalis has been implicated in this regard, the central nucleus of the amygdala (CeA) also receives a relaxin-3 innervation and CeA neurons densely express RXFP3 mRNA. Moreover, the CeA is consistently implicated in both stress and addictive disorders. Yohimbine precipitates relapse-like behaviour in rodents, although exactly how yohimbine induces relapse is ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
We thank Dr Johan Rosengren, School of Biomedical Sciences, University of Queensland, for the supply of R3 (B1-22) R and Dr Wylie W. Vale (in memoriam), Dr Paul E. Sawchenko and Dr Joan Vaughan from the Salk Institute for Biological Studies for the generous gift of the antisera against CRF. These studies were supported by a National Health and Medical Research Council (NHMRC) of Australia project grant (1079893) to A.J.L. and A.L.G., both of whom are NHMRC (Australia) Research Fellows (A.J.L. 1116930 and A.L.G. 1106330). L.C.W. is supported by an Australian Postgraduate Scholarship, and H.E.K. was supported by a Melbourne International Research Scholarship. We acknowledge the Victorian State Government Infrastructure Program.