Solar insolation in springtime influences age of onset of bipolar I disorder

M Bauer; T Glenn; M Alda; MA Aleksandrovich; OA Andreassen; E Angelopoulos; R Ardau; Y Ayhan; C Baethge; SR Bharathram; R Bauer; BT Baune; C Becerra-Palars; F Bellivier; RH Belmaker; M Berk; Y Bersudsky; Bicakci; H Birabwa-Oketcho; TD Bjella; L Bossini; J Cabrera; EYW Cheung; M Del Zompo; S Dodd; M Donix; B Etain; A Fagiolini; KN Fountoulakis; MA Frye; A Gonzalez-Pinto; JF Gottlieb; P Grof; H Harima; C Henry; ET Isometsä; S Janno; F Kapczinski; M Kardell; S Khaldi; S Kliwicki; B König; TL Kot; R Krogh; M Kunz; B Lafer; M Landén; ER Larsen; U Lewitzka; RW Licht; C Lopez-Jaramillo; G MacQueen; M Manchia; W Marsh; M Martinez-Cengotitabengoa; I Melle; F Meza-Urzúa; M Yee Ming; S Monteith; G Morken; E Mosca; R Munoz; SV Mythri; F Nacef; RK Nadella; FG Nery; RE Nielsen; C O'Donovan; A Omrani; Y Osher; H Østermark Sørensen; U Ouali; Y Pica Ruiz; M Pilhatsch; M Pinna; FDR da Ponte; D Quiroz; R Ramesar; N Rasgon; MS Reddy; A Reif; P Ritter; JK Rybakowski; K Sagduyu; M Scippa; E Severus; C Simhandl; DJ Stein; S Strejilevich; M Subramaniam; AH Sulaiman; K Suominen; H Tagata; Y Tatebayashi; L Tondo; C Torrent; AE Vaaler; J Veeh; E Vieta; B Viswanath

Journal article

Solar insolation in springtime influences age of onset of bipolar I disorder

M Bauer, T Glenn, M Alda, MA Aleksandrovich, OA Andreassen, E Angelopoulos, R Ardau, Y Ayhan, C Baethge, SR Bharathram, R Bauer, BT Baune, C Becerra-Palars, F Bellivier, RH Belmaker, M Berk, Y Bersudsky, undefined Bicakci, H Birabwa-Oketcho, TD Bjella Show all

Acta Psychiatrica Scandinavica | WILEY | Published : 2017

DOI: 10.1111/acps.12772

Abstract

Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania ..

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University of Melbourne Researchers

Bernhard Baune Author

Michael Berk Author

Grants

Awarded by Mayo Clinic

Funding Acknowledgements

Michael Berk is supported by an NHMRC Senior Principal Research Fellowship (1059660). Ole A Andreassen, Thomas DBjella and Ingrid Melle are supported by Research Council of Norway (223273) and KG Jebsen Stiftelsen. Ravi Nadella has received funding from the Accelerator program for Discovery in Brain disorders using Stem cells (ADBS), jointly funded by the Department of Biotechnology, Government of India, and the Pratiksha trust. Biju Viswanath has received funding by Department of Science and Technology INSPIRE scheme, Government of India. Mikael Landen was supported by grants from the Swedish Research Council (K2014-62X-14647-12-51 and K2010-61P-21568-01-4), the Swedish foundation for Strategic Research (KF10-0039), and the Swedish Federal Government under the LUA/ALF agreement (ALF 20130032, ALFGBG-142041).