Genomic landscape of human diversity across Madagascar
Denis Pierron, Margit Heiske, Harilanto Razafindrazaka, Ignace Rakoto, Nelly Rabetokotany, Bodo Ravololomanga, Lucien M-A Rakotozafy, Mireille Mialy Rakotomalala, Michel Razafiarivony, Bako Rasoarifetra, Miakabola Andriamampianina Raharijesy, Lolona Razafindralambo, undefined Ramilisonina, Fulgence Fanony, Sendra Lejamble, Olivier Thomas, Ahmed Mohamed Abdallah, Christophe Rocher, Amal Arachiche, Laure Tonaso Show all
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2017
Although situated ∼400 km from the east coast of Africa, Madagascar exhibits cultural, linguistic, and genetic traits from both Southeast Asia and Eastern Africa. The settlement history remains contentious; we therefore used a grid-based approach to sample at high resolution the genomic diversity (including maternal lineages, paternal lineages, and genome-wide data) across 257 villages and 2,704 Malagasy individuals. We find a common Bantu and Austronesian descent for all Malagasy individuals with a limited paternal contribution from Europe and the Middle East. Admixture and demographic growth happened recently, suggesting a rapid settlement of Madagascar during the last millennium. However,..View full abstract
Awarded by French National Research Agency (ANR)
We thank all participants in the study; the students and staff from the Institut de Civilisations/Musee d'Art et d'Archeologie who have contributed to the sampling across Madagascar (T. Ramaharoarivo, M. Ramaheninjohary, M. Felantsoa, S. Rakotonandrasana, F. Andrianjafy, N. Randrianarivelo, A. Jao, A. Rakotoarison, T. Rakotovao, G. Herisoa, A. Fanomezantsoa, N. Ratsimbazafy, S. Herifanomezanjo, N. Rakotondrasoa, J. Raharinoro, L. Rabearisoa, S. Razafiarivony, O. Noarizafy, H. Rasolonantenaina, N. Haifetra, H. Razafindrainibe, R. Rakotomalala, Ismael, T. Rasolondrainy, C. Rasolonirina, D. Razanatolonjanaharitovo, V. Razanatovo, Zova, and P. Ratsimiveh); R. Schroder for technical assistance; and E. Crubezy for his support. This research was funded by Region Aquitaine "Projet MAGE" (Monitoring of Monoclonal Antibodies Group in Europe); French National Research Agency (ANR) Grants ANR-12-PDOC-0037-01 "GENOMIX" and ANR-14-CE31-0013-01 "OceoAdapo"; and Le Service de Cooperation et d'Action Culturelle (SCAC) from l'Ambassade de France a Antananarivo, Region Midi-Pyrenees.