Journal article
Therapeutic targeting in nanomedicine: The future lies in recombinant antibodies
GA Pietersz, X Wang, ML Yap, B Lim, K Peter
Nanomedicine | FUTURE MEDICINE LTD | Published : 2017
Abstract
The unique chemical and functional properties of nanoparticles can be harnessed for the delivery of large quantities of various therapeutic biomolecules. Active targeting of nanoparticles by conjugating ligands that bind to target cells strongly facilitates accumulation, internalization into target cells and longer retention at the target site, with consequent enhanced therapeutic effects. Recombinant antibodies with high selectivity and availability for a vast range of targets will dominate the future. In this review, we systematically outline the tremendous progress in the conjugation of antibodies to nanoparticles and the clear advantages that recombinant antibodies offer in the therapeut..
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Funding Acknowledgements
K Peter was supported by a Principal Research Fellowship from the National Health and Medical Research Council (NHMRC) of Australia. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.