Journal article

Enlarged temporal lobes in Turner syndrome: An X-chromosome effect?

C Rae, P Joy, J Harasty, A Kemp, S Kuan, J Christodoulou, CT Cowell, M Coltheart

CEREBRAL CORTEX | OXFORD UNIV PRESS INC | Published : 2004

Abstract

Gender differences in brain morphology have previously been reported in the temporal lobe and an 'X-chromosome dosage effect' has been described in Turner syndrome (45,X). To examine this further, we investigated temporal lobe morphology, metabolism and function in nine children with non-mosaic Turner syndrome using magnetic resonance imaging, (1)H magnetic resonance spectroscopy and neuropsychological testing and compared outcomes with results from nine age-matched control girls (46,XX). Turner subjects were found to have significantly larger superior temporal lobes (P = 0.004) and middle temporal lobes (P = 0.047) than controls. The size of the temporal lobe was found to correlate negative..

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