Journal article

MECP2 genomic structure and function: insights from ENCODE

Jasmine Singh, Alka Saxena, John Christodoulou, David Ravine

NUCLEIC ACIDS RESEARCH | OXFORD UNIV PRESS | Published : 2008

Abstract

MECP2, a relatively small gene located in the human X chromosome, was initially described with three exons transcribing RNA from which the protein MeCP2 was translated. It is now known to have four exons from which two isoforms are translated; however, there is also evidence of additional functional genomic structures within MECP2, including exons potentially transcribing non-coding RNAs. Accompanying the recognition of a higher level of intricacy within MECP2 has been a recent surge of knowledge about the structure and function of human genes more generally, to the extent that the definition of a gene is being revisited. It is timely now to review the published and novel functional elements..

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Grants

Awarded by NH & MRC Biomedical postdoctoral fellowship


Funding Acknowledgements

Robert Vandongen Vacation Scholarship awarded by the Royal Perth Hospital Medical Research Foundation to J.S. A.S. is supported by an NH & MRC Biomedical postdoctoral fellowship 404132.