Journal article

Immunometabolic and Lipidomic Markers Associated With the Frailty Index and Quality of Life in Aging HIV Men on Antiretroviral Therapy

Hui-Ling Yeoh, Allen C Cheng, Catherine L Cherry, Jacquelyn M Weir, Peter J Meikle, Jennifer F Hoy, Suzanne M Crowe, Clovis S Palmer

EBIOMEDICINE | ELSEVIER SCIENCE BV | Published : 2017

Abstract

Chronic immune activation persists despite antiretroviral therapy (ART) in HIV+ individuals and underpins an increased risk of age-related co-morbidities. We assessed the Frailty Index in older HIV+ Australian men on ART. Immunometabolic markers on monocytes and T cells were analyzed using flow cytometry, plasma innate immune activation markers by ELISA, and lipidomic profiling by mass spectrometry. The study population consisted of 80 HIV+ men with a median age of 59 (IQR, 56-65), and most had an undetectable viral load (92%). 24% were frail, and 76% were non-frail. Frailty was associated with elevated Glucose transporter-1 (Glut1) expression on the total monocytes (p=0.04), increased plasm..

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Grants

Awarded by NIH - NIH Institute and Center (NIAID)


Awarded by NIH - NIH Institute and Center (NCI)


Awarded by NIH - NIH Institute and Center (NIMH)


Awarded by NIH - NIH Institute and Center (NIDA)


Awarded by NIH - NIH Institute and Center (NICHD)


Awarded by NIH - NIH Institute and Center (NHLBI)


Awarded by NIH - NIH Institute and Center (NIA)


Funding Acknowledgements

This group received a grant from Merck Sharp & Dohme for the materials of this study. The funding sources had no role in designing the study, in collecting, analyzing, interpreting or reporting the data, or in deciding to submit the article for publication. C.S.P. is a recipient of the Australian Centre for HIV and Hepatitis Virology Research (ACH2) grant, and a 2010 developmental grant (CNIHR) from the University of Washington Center for AIDS Research (CFAR), an NIH funded program under award number AI027757 which is supported by the following NIH Institutes and Centers (NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA). Some assays employed in this study were developed under these funding schemes. There was no other funding source for this study.