Journal article

Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations

Joseph V Moxon, Rhondda E Jones, Gerard Wong, Jacquelyn M Weir, Natalie A Mellett, Bronwyn A Kingwell, Peter J Meikle, Jonathan Golledge



BACKGROUND AND AIMS: Despite current best care, patients with peripheral artery disease (PAD) remain at high risk of myocardial infarction, and biomarkers to more accurately assess cardiovascular risk are needed. This study assessed the relationship between the serum lipidome and incident myocardial infarction in a cohort of PAD patients. METHODS: 265 PAD patients were followed up for a median of 23 months, during which 18 people suffered a myocardial infarction. Fasting serum concentrations of 332 lipid species were measured via mass spectrometry and their association with incident myocardial infarction was assessed via Cox regression. Secondary analyses investigated prognostic potential of..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Australia

Awarded by NHMRC

Funding Acknowledgements

This work was supported by grants from the Queensland Government, James Cook University, the National Health and Medical Research Council (NHMRC: 1020955; 1022752; 1000967, 1029754), and the Victorian State Government Operational Infrastructure support scheme. JVM is the recipient of an Advance Queensland Fellowship from the Queensland Government. JG holds a Practitioner Fellowship from the NHMRC Australia (1117061), and a Senior Clinical Research Fellowship from the Queensland Government. PJM is an NHMRC Senior Research Fellow (1042095) and BAK an NHMRC Senior Principal Research Fellow (1059454). The funding bodies played no role in study design, data acquisition and analysis or manuscript preparation.