Impact of Results of a Rapid Staphylococcus aureus Diagnostic Test on Prescribing of Antibiotics for Patients with Clustered Gram-Positive Cocci in Blood Cultures
Jane Davies, Claire L Gordon, Steven YC Tong, Robert W Baird, Joshua S Davis
JOURNAL OF CLINICAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 2012
In tropical northern Australia, approximately 20% of Staphylococcus aureus bacteremia is caused by methicillin-resistant Staphylococcus aureus (MRSA). We prospectively evaluated the impact on clinician antibiotic prescribing of the results obtained from performing the GeneXpert MRSA/SA test on 151 positive blood cultures with clustered gram-positive cocci. The GeneXpert result led to earlier appropriate prescription of vancomycin for 54% of patients with MRSA; 25% of patients avoided vancomycin, and 16% of patients had all antibiotics ceased.
Awarded by Australian National Health and Medical Research Council (NHMRC)
This study was supported by a government research grant from the Northern Territory Research and Innovation Board. J.S.D. (grant 1013411) and S.Y.C.T. (grant 508829) are Australian National Health and Medical Research Council (NH&MRC) postdoctoral training fellows.