Journal article
Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management
SYC Tong, JS Davis, E Eichenberger, TL Holland, VG Fowler
Clinical Microbiology Reviews | AMER SOC MICROBIOLOGY | Published : 2015
DOI: 10.1128/CMR.00134-14
Abstract
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
V.G.F. is supported by grants R01-AI068804 and K24-AI093969 from the National Institutes of Health. T.L.H. has been a paid consultant for The Medicines Company. V.G.F. served as Chair of the V710 Scientific Advisory Committee (Merck); has received grant support or has grants pending from Cerexa, Pfizer, Advanced Liquid Logic, MedImmune, and Cubist; has been a paid consultant for Merck, Astellas, Affinium, Theravance, Cubist, Cerexa, Durata, Pfizer, NovaDigm, Novartis, The Medicines Company, Biosynexus, MedImmune, Inimex, and Bayer; and has received honoraria from Merck, Astellas, Cubist, Pfizer, Theravance, and Novartis. S.Y.C.T., J.S.D., and E.E. have no conflicts of interest to declare.