Hepatocellular carcinoma in Australia's Northern Territory: high incidence and poor outcome
Christopher Parker, Steven YC Tong, Karen Dempsey, John Condon, Suresh K Sharma, John WC Chen, William Sievert, Joshua S Davis
MEDICAL JOURNAL OF AUSTRALIA | AUSTRALASIAN MED PUBL CO LTD | Published : 2014
OBJECTIVE: To describe the epidemiology, clinical features, management and outcomes of hepatocellular carcinoma (HCC) in the Northern Territory over the past decade. DESIGN, SETTING AND PATIENTS: An NT-wide epidemiology study covering the period 1991-2010 and a clinical cohort study including patients diagnosed during 2000-2011. HCC diagnoses were provided by the NT Cancer Registry and cross-checked against clinical records. MAIN OUTCOME MEASURES: Age-adjusted incidence of HCC; management; clinical features; and median and 1-year survival. RESULTS: There were 145 incident cases of HCC in the NT during 1991-2010, giving an age-adjusted annual incidence of 22.7/100 000 (95% CI, 17.2-26.8) for ..View full abstract
We thank Libby John, Darren Mounkley, Ramon Pathi and Mark Brooke-Smith from Flinders Medical Centre; and Krispin Hajkowicz, Jane Davies and all the registrars from the Royal Darwin Hospital liver clinic for helping with clinical management of the patients in this study. We thank Mark Loewenthal for statistical advice. National Health and Medical Research Council early career fellowships provided salary support for Joshua Davis and Steven Tong.