Journal article
Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus
BK Sharma-Kuinkel, SH Ahn, TH Rude, Y Zhang, SYC Tong, F Ruffin, FC Genter, KR Braughton, FR DeLeo, SL Barriere, VG Fowler
Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2012
DOI: 10.1128/JCM.06219-11
Abstract
The impact of Panton-Valentine leukocidin (PVL) on the outcome in Staphylococcus aureus pneumonia is controversial. We genotyped S. aureus isolates from patients with hospital-acquired pneumonia (HAP) enrolled in two registrational multinational clinical trials for the genetic elements carrying pvl and 30 other virulence genes. A total of 287 isolates (173 methicillin-resistant S. aureus [MRSA] and 114 methicillin-susceptible S. aureus [MSSA] isolates) from patients from 127 centers in 34 countries for whom clinical outcomes of cure or failure were available underwent genotyping. Of these, pvl was detected by PCR and its product confirmed in 23 isolates (8.0%) (MRSA, 18/173 isolates [10.4%];..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This study was supported by a grant from Theravance, Inc., South San Francisco, CA. V.G. Fowler was supported in part by K24 AI093969 from the National Institutes of Health. This research was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health. S. Y. C. Tong is supported by an Australian National Health and Medical Research Council Postdoctoral Training Fellowship (508829), an Australian-American Fulbright Scholarship, and a Royal Australasian College of Physicians Bayer Australia Medical Research Fellowship.