Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users
Mieke HJ Schulte, Anne Marije Kaag, Reinout W Wiers, Lianne Schmaal, Wim van den Brink, Liesbeth Reneman, Judith R Homberg, Guido A van Wingen, Anna E Goudriaan
DRUG AND ALCOHOL DEPENDENCE | ELSEVIER IRELAND LTD | Published : 2017
Glutamate and GABA play an important role in substance dependence. However, it remains unclear whether this holds true for different substance use disorders and how this is related to risk-related traits such as impulsivity. We, therefore, compared Glx (as a proxy measure for glutamate) and GABA concentrations in the dorsal anterior cingulate cortex (dACC) of 48 male cigarette smokers, 61 male smoking polysubstance users, and 90 male healthy controls, and investigated the relationship with self-reported impulsivity and substance use. Glx and GABA concentrations were measured using proton Magnetic Resonance Spectroscopy. Impulsivity, smoking, alcohol and cocaine use severity and cannabis use ..View full abstract
Awarded by NWO (Dutch National Science Foundation)
Awarded by ZonMW
Study A was supported by a grant from the NWO (Dutch National Science Foundation), awarded to the Dutch-Flemish Research School Experimental Psychopathology (grant number 022.003.038). Study B was supported by a grant provided by ZonMW (grant number 91211002).