Journal article
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: An individual patient data meta-analysis
S Abdulla, EA Ashley, Q Bassat, D Bethell, A Björkman, S Borrmann, U D’Alessandro, P Dahal, NP Day, M Diakite, AA Djimde, AM Dondorp, S Duong, MD Edstein, RM Fairhurst, M Abul Faiz, C Falade, JA Flegg, C Fogg, R Gonzalez Show all
Malaria Journal | BMC | Published : 2015
Abstract
Background: Artemisinin resistance in Plasmodium falciparum manifests as slow parasite clearance but this measure is also influenced by host immunity, initial parasite biomass and partner drug efficacy. This study collated data from clinical trials of artemisinin derivatives in falciparum malaria with frequent parasite counts to provide reference parasite clearance estimates stratified by location, treatment and time, to examine host factors affecting parasite clearance, and to assess the relationships between parasite clearance and risk of recrudescence during follow-up. Methods: Data from 24 studies, conducted from 1996 to 2013, with frequent parasite counts were pooled. Parasite clearance..
View full abstractGrants
Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
We thank the patients and staff who participated in the clinical trials at all sites. WWARN is funded by a Bill and Melinda Gates Foundation grant. The funder did not participate in developing the protocol or writing the paper. This study was supported in part by the Intramural Research Program of the NIAID, NIH. All clinical studies were approved by the respective ethics committees or institutional review boards of each collaborative entity and host country of conduct. All subjects provided informed consent before study participation, and parents or legal guardians provided informed consent on behalf of their children. Disclaimer: The opinions expressed are those of the authors and do not necessarily reflect those of the Australian Defence Organisation or any extant policy.