Journal article
Perfusion computed tomography in patients with stroke thrombolysis
H Kawano, A Bivard, L Lin, H Ma, X Cheng, R Aviv, B O’Brien, K Butcher, M Lou, J Zhang, J Jannes, Q Dong, CR Levi, MW Parsons
Brain | OXFORD UNIV PRESS | Published : 2017
DOI: 10.1093/brain/aww338
Abstract
Stroke shortens an individual’s disability-free life. We aimed to assess the relative prognostic influence of pre- and post-treatment perfusion computed tomography imaging variables (e.g. ischaemic core and penumbral volumes) compared to standard clinical predictors (such as onset-to-treatment time) on long-term stroke disability in patients undergoing thrombolysis. We used data from a prospectively collected international, multicentre, observational registry of acute ischaemic stroke patients who had perfusion computed tomography and computed tomography angiography before treatment with intravenous alteplase. Baseline perfusion computed tomography and follow-up magnetic resonance imaging we..
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Awarded by Shanghai Municipal Health Bureau
Funding Acknowledgements
This study was funded by National Health and Medical Research Council Partnership Project (ID: APP1013719) 2011-2015. H.K. reports fellowship from Daiichi-Sankyo Foundation of Life Science. A.B. reports grant from National Health and Medical Research Council early career fellowship. X.C. reports grants from Science and Technology Commission of the Shanghai Municipality (Grant no. 124119a8100), grants from Science and Technology Commission of the Shanghai Municipality (Shanghai Rising-Star Program: 15QA1400900). R.A. reports grants from Canadian Institutes of Health Research, Biogen foundation fellowship award. K.B. reports a Canada Research Chair in Cerebrovascular Disease, the Heart and Stroke Foundation of Alberta Professorship in Stroke Medicine, an Alberta Innovates Health Solutions Clinical Investigator Award and grant in aid funding from the Canadian Institutes for Health Research and the Heart and Stroke Foundation of Canada. J.J. reports grants from The Queen Elizabeth Hospital. CRL reports grant from National Health and Medical Research Council Practitioner Fellowship (APP1043913). M.W.P. reports grant from Australian Research Council Future Fellowship (FT0991128). L.L., H.M., B.O., M.L., J.Z., and Q.D. have nothing to disclose.