Age-Related Decline in Task Switching is Linked to Both Global and Tract-Specific Changes in White Matter Microstructure
Todd AD Jolly, Patrick S Cooper, Jaime L Rennie, Christopher R Levi, Rhoshel Lenroot, Mark W Parsons, Patricia T Michie, Frini Karayanidis
HUMAN BRAIN MAPPING | WILEY | Published : 2017
Task-switching performance relies on a broadly distributed frontoparietal network and declines in older adults. In this study, they investigated whether this age-related decline in task switching performance was mediated by variability in global or regional white matter microstructural health. Seventy cognitively intact adults (43-87 years) completed a cued-trials task switching paradigm. Microstructural white matter measures were derived using diffusion tensor imaging (DTI) analyses on the diffusion-weighted imaging (DWI) sequence. Task switching performance decreased with increasing age and radial diffusivity (RaD), a measure of white matter microstructure that is sensitive to myelin struc..View full abstract
Awarded by Australian Research Council
Contract grant sponsor: Hunter Medical Research (HMRI) Project Grant to FK, CL, MP and PM and an Australian Research Council - Discovery Project (DP120100340) Award (APA) (TJ, PC), by an HMRI Research Higher Degree Scholarship (TJ), and University of Newcastle Postgraduate Research Scholarship (JR).