Journal article

The velocity of collateral filling predicts recanalization in acute ischemic stroke after intravenous thrombolysis

Sheng Zhang, Xiaocheng Zhang, Shenqiang Yan, Yangxiao Lai, Quan Han, Jianzhong Sun, Minming Zhang, Mark W Parsons, Shaoshi Wang, Min Lou

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2016

Abstract

The aim of this study was to evaluate the impact of pretreatment quality of collaterals, involving velocity and extent of collateral filling, on recanalization after intravenous thrombolysis (IVT). A retrospective analysis was performed of 66 patients with acute middle cerebral artery (MCA) M1 segment occlusion who underwent MR perfusion (MRP) imaging before IVT. The velocity of collateral filling was defined as arrival time delay (ATD) of contrast bolus to Sylvian fissure between the normal and the affected hemisphere. The extent of collateral filling was assessed according to the Alberta Stroke Program Early CT (ASPECT) score on temporally fused maximum intensity projections (tMIP). Arteri..

View full abstract

Grants

Awarded by Science Technology Department of Zhejiang Province


Awarded by National Natural Science Foundation of China


Funding Acknowledgements

This work was supported by the Science Technology Department of Zhejiang Province (2013C13G2010032) and the National Natural Science Foundation of China (81471170). The perfusion analysis software (MIStar) used in this study was provided to the site as part of their involvement in the International Stroke Perfusion Imaging Registry (INSPIRE, www.Inspire.apollomit.com/), study funded by the National Health and Medical Research Council of Australia.