Journal article

Microstructural white matter changes mediate age-related cognitive decline on the Montreal Cognitive Assessment (MoCA)

Todd AD Jolly, Patrick S Cooper, Syarifah Azizah Wan Ahmadul Badwi, Natalie A Phillips, Jaime L Rennie, Christopher R Levi, Karen A Drysdale, Mark W Parsons, Patricia T Michie, Frini Karayanidis



Although the relationship between aging and cognitive decline is well established, there is substantial individual variability in the degree of cognitive decline in older adults. The present study investigates whether variability in cognitive performance in community-dwelling older adults is related to the presence of whole brain or tract-specific changes in white matter microstructure. Specifically, we examine whether age-related decline in performance on the Montreal Cognitive Assessment (MoCA), a cognitive screening tool, is mediated by the white matter microstructural decline. We also examine if this relationship is driven by the presence of cardiovascular risk factors or variability in ..

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Awarded by Australian Research Council

Funding Acknowledgements

We thank the Hunter Medical Research Institute (HMRI) Research Register for recruitment of healthy participants and Kristy Morris for recruitment of patients. The protocol was approved by the Hunter New England Human Research Ethics Committee (HNEHREC Approval No: 10/03/17/5.04). This work was funded by an HMRI project grant to FK, CRL, MWP, and PTM and an Australian Research Council-Discovery Project (DP120100340) to FK, MWP, and PTM. TADJ, PSC, and JLR were supported by an Australian Postgraduate Award (APA) and TADJ by an HMRI Research Higher Degree Scholarship.