Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: studies in a rat stroke model.
DD McLeod, MW Parsons, R Hood, B Hiles, J Allen, SK McCann, L Murtha, MB Calford, CR Levi, NJ Spratt
Int J Stroke | Published : 2015
BACKGROUND: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stroke and guide reperfusion therapies. AIMS: The study aims to determine whether there are important changes in perfusion computed tomography thresholds defining ischemic penumbra and infarct core over time following stroke. METHODS: Permanent middle cerebral artery occlusion was performed in adult outbred Wistar rats (n = 6) and serial perfusion computed tomography scans were taken every 30 mins for 2 h. To define infarction thresholds at 1 h and 2 h post-stroke, separate groups of rats underwent 1 h (n = 6) and 2 h (..View full abstract