HOBOE (head-of-bed optimization of elevation) study: Association of higher angle with reduced cerebral blood flow velocity in acute ischemic stroke

Abstract

Background: Cerebral autoregulation can be impaired after ischemic stroke, with potential adverse effects on cerebral blood flow during early rehabilitation. Objective: The objective of this study was to assess changes in cerebral blood flow velocity with orthostatic variation at 24 hours after stroke. Design. This investigation was an observational study comparing mean flow velocities (MFVs) at 30, 15, and 0 degrees of elevation of the head of the bed (HOB). Methods: Eight participants underwent bilateral middle cerebral artery (MCA) transcranial Doppler monitoring during orthostatic variation at 24 hours after ischemic stroke. Computed tomography angiography separated participants into rec..