Journal article
Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR.
Niaz Ahmed, Nils Wahlgren, Martin Grond, Michael Hennerici, Kennedy R Lees, Robert Mikulik, Mark Parsons, Risto O Roine, Danilo Toni, Peter Ringleb, undefined SITS investigators
Lancet Neurol | Published : 2010
Abstract
BACKGROUND: In September, 2008, the European Acute Stroke Study III (ECASS III) randomised trial and the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry (SITS-ISTR) observational study reported the efficacy and safety of the extension of the time window for intravenous alteplase treatment from within 3 h to within 4.5 h after stroke onset. We aimed to assess the implementation of the wider time window, its effect on the admission-to-treatment time, and safety and functional outcome in patients recorded in SITS-ISTR. METHODS: Patients treated according to the criteria of the European Summary of Product Characteristics, except for the time window, were inc..
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