The Mechanisms for Within-Host Influenza Virus Control Affect Model-Based Assessment and Prediction of Antiviral Treatment
Pengxing Cao, James M McCaw
Viruses | MDPI AG | Published : 2017
Models of within-host influenza viral dynamics have contributed to an improved understanding of viral dynamics and antiviral effects over the past decade. Existing models can be classified into two broad types based on the mechanism of viral control: models utilising target cell depletion to limit the progress of infection and models which rely on timely activation of innate and adaptive immune responses to control the infection. In this paper, we compare how two exemplar models based on these different mechanisms behave and investigate how the mechanistic difference affects the assessment and prediction of antiviral treatment. We find that the assumed mechanism for viral control strongly in..View full abstract
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Awarded by Centre for Research Excellence PRISM2
Awarded by Australian Research Council
We would like to thank Ada Wing Chi Yan for helpful comments and conversations. The work is supported by the National Health and Medical Research Council of Australia, the Centre for Research Excellence PRISM2 [grant number 1078068] and the Australian Research Council Discovery Project [grant number DP170103076].